Eukaryotic Ribosome Assembly, Quality Control and Export

Vikram G. Panse; Christine S. Weirich; Michaela Oborská-Oplová

doi:10.1016/B978-0-12-821618-7.00185-1

Eukaryotic Ribosome Assembly, Quality Control and Export

Vikram G. Panse, Christine S. Weirich, Michaela Oborská-Oplová

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Eukaryotic ribosome assembly spans three cellular compartments and requires the concerted action of three RNA polymerases, the splicing and nucleocytoplasmic transport machinery. This process also requires >200 transiently interacting factors including a range of energy-consuming enzymes and RNA-binding scaffolds, that perform both assembly and proofreading functions. Although the detailed mechanisms of ribosome formation have not yet been fully elucidated, a general framework for this process has emerged from a combination of genetic, biochemical, and structural approaches applied to the model organism budding yeast. Here, we review the current state of knowledge of yeast ribosome assembly, quality control and nuclear export.

Original language	English (US)
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	87-105
Number of pages	19
Volume	5
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00185-1
State	Published - Jan 1 2022

Keywords

Cytoplasm
Large subunit
Nucleocytoplasmic transport
Nucleolus
Nucleus
RNA processing
Ribosomal RNA
Ribosomal protein
Ribosome
Ribosome biogenesis
Small subunit

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-821618-7.00185-1

Cite this

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title = "Eukaryotic Ribosome Assembly, Quality Control and Export",

abstract = "Eukaryotic ribosome assembly spans three cellular compartments and requires the concerted action of three RNA polymerases, the splicing and nucleocytoplasmic transport machinery. This process also requires >200 transiently interacting factors including a range of energy-consuming enzymes and RNA-binding scaffolds, that perform both assembly and proofreading functions. Although the detailed mechanisms of ribosome formation have not yet been fully elucidated, a general framework for this process has emerged from a combination of genetic, biochemical, and structural approaches applied to the model organism budding yeast. Here, we review the current state of knowledge of yeast ribosome assembly, quality control and nuclear export.",

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AU - Weirich, Christine S.

AU - Oborská-Oplová, Michaela

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N2 - Eukaryotic ribosome assembly spans three cellular compartments and requires the concerted action of three RNA polymerases, the splicing and nucleocytoplasmic transport machinery. This process also requires >200 transiently interacting factors including a range of energy-consuming enzymes and RNA-binding scaffolds, that perform both assembly and proofreading functions. Although the detailed mechanisms of ribosome formation have not yet been fully elucidated, a general framework for this process has emerged from a combination of genetic, biochemical, and structural approaches applied to the model organism budding yeast. Here, we review the current state of knowledge of yeast ribosome assembly, quality control and nuclear export.

AB - Eukaryotic ribosome assembly spans three cellular compartments and requires the concerted action of three RNA polymerases, the splicing and nucleocytoplasmic transport machinery. This process also requires >200 transiently interacting factors including a range of energy-consuming enzymes and RNA-binding scaffolds, that perform both assembly and proofreading functions. Although the detailed mechanisms of ribosome formation have not yet been fully elucidated, a general framework for this process has emerged from a combination of genetic, biochemical, and structural approaches applied to the model organism budding yeast. Here, we review the current state of knowledge of yeast ribosome assembly, quality control and nuclear export.

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KW - Large subunit

KW - Nucleocytoplasmic transport

KW - Nucleolus

KW - Nucleus

KW - RNA processing

KW - Ribosomal RNA

KW - Ribosomal protein

KW - Ribosome

KW - Ribosome biogenesis

KW - Small subunit

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M3 - Chapter

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VL - 5

SP - 87

EP - 105

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Eukaryotic Ribosome Assembly, Quality Control and Export

Abstract

Keywords

ASJC Scopus subject areas

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