Eukaryotic circadian systems: Cycles in common

Jay C. Dunlap, Jennifer J. Loros, Yi Liu, Susan K. Crosthwaite

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Common regulatory patterns can now be discerned among eukaryotic circadian systems, extending from fungi through to mammals. Complexes of two distinct PAS domain-containing transcription factors play positive roles in clock-associated feedback loops by turning on classic clock proteins such as FRQ, PER and TIM. These in turn appear to act as negative elements, interfering with their own activation and thus giving rise to an oscillatory negative feedback loop. Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalGenes to Cells
Issue number1
StatePublished - 1999

ASJC Scopus subject areas

  • Genetics
  • Cell Biology


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