Abstract
Changes in heart rate and systolic blood pressure were measured during extubation and emergence from anesthesia in 40 ASA physical status I and II patients in a double-blind study to assess the effect of three doses of esmolol (1, 1.5, and 2 mg/kg) given as a bolus 2 min after reversal of neuromuscular blockade. Heart rate (P 0.01), systolic blood pressure (P < 0.02), and rate-pressure product (P < 0.01) increased significantly during extubation of the control group. All doses of esmolol attenuated the increases in heart rate, but 1 mg/kg was insufficient to control the increase in systolic blood pressure. Doses of 1.5 and 2 mg/kg controlled both systolic blood pressure and heart rate, but the larger dose produced significant decreases in systolic blood pressure.
Original language | English (US) |
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Pages (from-to) | 675-678 |
Number of pages | 4 |
Journal | Anesthesia and analgesia |
Volume | 71 |
Issue number | 6 |
DOIs | |
State | Published - 1990 |
Keywords
- anesthetic techniques, extubation-esmolol
- sympathetic nervous system, pharmacology-esmolol
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine