Esmolol attenuates cardiovascular responses to extubation

A. Dyson, P. A. Isaac, J. H. Pennant, A. H. Giesecke, J. M. Lipton

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Changes in heart rate and systolic blood pressure were measured during extubation and emergence from anesthesia in 40 ASA physical status I and II patients in a double-blind study to assess the effect of three doses of esmolol (1, 1.5, and 2 mg/kg) given as a bolus 2 min after reversal of neuromuscular blockade. Heart rate (P 0.01), systolic blood pressure (P < 0.02), and rate-pressure product (P < 0.01) increased significantly during extubation of the control group. All doses of esmolol attenuated the increases in heart rate, but 1 mg/kg was insufficient to control the increase in systolic blood pressure. Doses of 1.5 and 2 mg/kg controlled both systolic blood pressure and heart rate, but the larger dose produced significant decreases in systolic blood pressure.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalAnesthesia and analgesia
Issue number6
StatePublished - 1990


  • anesthetic techniques, extubation-esmolol
  • sympathetic nervous system, pharmacology-esmolol

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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