Error-prone DNA polymerases: Novel structures and the benefits of infidelity

Errol C. Friedberg; Paula L. Fischhaber; Caroline Kisker

doi:10.1016/S0092-8674(01)00509-8

Error-prone DNA polymerases: Novel structures and the benefits of infidelity

Errol C. Friedberg, Paula L. Fischhaber, Caroline Kisker

Research output: Contribution to journal › Review article › peer-review

110 Scopus citations

Abstract

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Cell
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/S0092-8674(01)00509-8
State	Published - Oct 5 2001

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(01)00509-8

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title = "Error-prone DNA polymerases: Novel structures and the benefits of infidelity",

abstract = "Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.",

author = "Friedberg, {Errol C.} and Fischhaber, {Paula L.} and Caroline Kisker",

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T2 - Novel structures and the benefits of infidelity

AU - Friedberg, Errol C.

AU - Fischhaber, Paula L.

AU - Kisker, Caroline

PY - 2001/10/5

Y1 - 2001/10/5

N2 - Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

AB - Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

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M3 - Review article

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JO - Cell

JF - Cell

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Error-prone DNA polymerases: Novel structures and the benefits of infidelity

Abstract

ASJC Scopus subject areas

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