ERKs, extracellular signal-regulated MAP-2 kinases

Melanie H. Cobb, David J. Robbins, Teri G. Boulton

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


A family of protein kinases, known alternatively as microtubule-associated protein-2/myelin basic protein kinases or extracellular signal-regulated kinases, is activated by numerous hormones, growth factors and other extracellular stimuli. At least two members of this family function as intermediate kinases in protein phosphorylation cascades. Their mechanisms of activation may involve autophosphorylation, which occurs on both threonine and tyrosine residues.

Original languageEnglish (US)
Pages (from-to)1025-1032
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Cell Biology


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