Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

J R Falck; L. Manmohan Reddy; Kihwan Byun; William B. Campbell; Xiu Yu Yi

doi:10.1016/j.bmcl.2007.01.096

Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

J R Falck, L. Manmohan Reddy, Kihwan Byun, William B. Campbell, Xiu Yu Yi

Biochemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

Original language	English (US)
Pages (from-to)	2634-2638
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2007.01.096
State	Published - May 1 2007

Keywords

EETs
Eicosanoids
Epoxygenase
Tetrahydrofuran
Vasorelaxation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2007.01.096

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title = "Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity",

abstract = "Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.",

keywords = "EETs, Eicosanoids, Epoxygenase, Tetrahydrofuran, Vasorelaxation",

author = "Falck, {J R} and {Manmohan Reddy}, L. and Kihwan Byun and Campbell, {William B.} and Yi, {Xiu Yu}",

note = "Funding Information: Financial support was provided by the Robert A. Welch Foundation and NIH (GM31278, DK38226, and HL-51055). Dr. Elaine R. Fogel is thanked for helpful discussions.",

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AU - Falck, J R

AU - Manmohan Reddy, L.

AU - Byun, Kihwan

AU - Campbell, William B.

AU - Yi, Xiu Yu

N1 - Funding Information: Financial support was provided by the Robert A. Welch Foundation and NIH (GM31278, DK38226, and HL-51055). Dr. Elaine R. Fogel is thanked for helpful discussions.

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

AB - Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

KW - EETs

KW - Eicosanoids

KW - Epoxygenase

KW - Tetrahydrofuran

KW - Vasorelaxation

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Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

Abstract

Keywords

ASJC Scopus subject areas

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