Ephrin reverse signaling in axon guidance and synaptogenesis

Nan Jie Xu, Mark Henkemeyer

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Axon-cell and axon-dendrite contact is a highly regulated process necessary for the formation of precise neural circuits and a functional neural network. Eph-ephrin interacting molecules on the membranes of axon nerve terminals and target dendrites act as bidirectional ligands/receptors to transduce signals into both the Eph-expressing and ephrin-expressing cells to regulate cytoskeletal dynamics. In particular, recent evidence indicates that ephrin reverse signal transduction events are important in controlling both axonal and dendritic elaborations of neurons in the developing nervous system. Here we review how ephrin reverse signals are transduced into neurons to control maturation of axonal pre-synaptic and dendritic post-synaptic structures.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalSeminars in Cell and Developmental Biology
Issue number1
StatePublished - Feb 2012


  • Axon
  • Dendrite
  • Ephrin
  • Neuron
  • Reverse signaling
  • Synapse

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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