EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding

Michael A. Robichaux, George Chenaux, Hsin Yi Henry Ho, Michael J. Soskis, Christopher Dravis, Kenneth Y. Kwan, Nenad Sestan, Michael Eldon Greenberg, Mark Henkemeyer, Christopher W. Cowan

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


In early brain development, ascending thalamocortical axons (TCAs) navigate through the ventral telencephalon (VTel) to reach their target regions in the young cerebral cortex. Descending, deep-layer cortical axons subsequently target appropriate thalamic and subcortical target regions. However, precisely how and when corticothalamic axons (CTAs) identify their appropriate, reciprocal thalamic targets remains unclear. We show here that EphB1 and EphB2 receptors control proper navigation of a subset of TCA and CTA projections through the VTel. We show in vivo that EphB receptor forward signaling and the ephrinB1 ligand are required during the early navigation of L1-CAM+ thalamic fibers in the VTel, and that the misguided thalamic fibers in EphB1/2 KO mice appear to interact with cortical subregion-specific axon populations during reciprocal cortical axon guidance. As such, our findings suggest that descending cortical axons identify specific TCA subpopulations in the dorsal VTel to coordinate reciprocal cortical- thalamic connectivity in the early developing brain.

Original languageEnglish (US)
Pages (from-to)2188-2193
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number6
StatePublished - Feb 11 2014

ASJC Scopus subject areas

  • General


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