Enzymes Involved in AMPylation and deAMPylation

Amanda K. Casey, Kim Orth

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Posttranslational modifications are covalent changes made to proteins that typically alter the function or location of the protein. AMPylation is an emerging posttranslational modification that involves the addition of adenosine monophosphate (AMP) to a protein. Like other, more well-studied posttranslational modifications, AMPylation is predicted to regulate the activity of the modified target proteins. However, the scope of this modification both in bacteria and in eukaryotes remains to be fully determined. In this review, we provide an up to date overview of the known AMPylating enzymes, the regulation of these enzymes, and the effect of this modification on target proteins.

Original languageEnglish (US)
Pages (from-to)1199-1215
Number of pages17
JournalChemical Reviews
Issue number3
StatePublished - Feb 14 2018

ASJC Scopus subject areas

  • Chemistry(all)


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