ENU mutagenesis in mice.

Philippe Georgel, Xin Du, Kasper Hoebe, Bruce Beutler

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Forward genetics has led to many "breakthrough" discoveries, and with the mouse genome almost fully sequenced, the creation of phenotypes through random germline mutagenesis has become an efficient means by which to find the function of yet undescribed genes. In this chapter, we will provide a practical guideline for performing germline mutagenesis in mice. In particular, we will focus on the application of this technology to identify genes that are essential to innate immune defense.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalMethods in molecular biology (Clifton, N.J.)
StatePublished - 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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