Abstract
There are sparse clinical data addressing the persistence of disordered coagulation in sepsis and its role in chronic critical illness. Coagulopathy in the absence of anticoagulant therapy and/or liver disease can be highly variable in sepsis, but it tends to be prolonged in patients in the intensive care unit with a length of stay greater than 14 days. These coagulation abnormalities tend to precede multisystem organ failure and persistence of these coagulation derangements can predict 28-day mortality. The studies evaluated in this review consistently link sepsis-associated coagulopathy to poor long-term outcomes and indicate that disordered coagulation is associated with unfavorable outcomes in chronic critical illness. However, the causative mechanism and the definitive link remain unclear. Longer follow-up and more granular data will be required to fully understand coagulopathy in the context of chronic critical illness.
Original language | English (US) |
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Article number | e000462 |
Journal | Trauma Surgery and Acute Care Open |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - Oct 16 2020 |
Externally published | Yes |
Keywords
- blood coagulation
- multiple organ failure
- sepsis
ASJC Scopus subject areas
- Surgery
- Critical Care and Intensive Care Medicine