Enhancement of renal excretion of zinc by hydrochlorothiazide

Charles Y C Pak, Belle Ruskin, Esther Diller

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The effect of hydrochlorothiazide (50 mg twice a day orally for 5 days) on the metabolism of zinc was examined in four patients with idiopathic hypercalciuria, one with idiopathic osteoporosis, one with normocalciuric nephrolithiasis, one normal volunteer, and one with normocalcemic primary hyperparathyroidism. Urinary zinc progressively increased until the peak value, at approximately twice the mean of control values, was reached on the fifth day of treatment with hydrochlorothiazide. After treatment was stopped, it gradually decreased towards control values. Serum concentration of zinc increased slightly or did not change during treatment. In contrast, furosemide, triamterene, mercaptomerin, or oral "sodium loading" did not affect renal excretion of zinc.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalClinica Chimica Acta
Issue number2
StatePublished - Jul 1972

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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