Enhanced contrast dual modality imaging approach for screening of epithelial cancers

Nicusor Iftimia, Anton Chestukin, Daniel Hammer, Teoman Ustun, Mircea Mujat, Jinda Fan, Yupeng Ye, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A novel approach for epithelial cancer screening based on the use of a high specificity cancer targeting contrast agent in combination with a dual imaging capability, fluorescence guided optical coherence tomography (OCT), is presented. An RGD peptide labeled with a NIR fluorescent carbocyanine dye (cypate) is used as a contrast agent for fluorescence imaging. The RGD peptide recognizes the αvβ3 integrin receptor (ABIR) which is over-expressed by epithelial cancer cells. While OCT allows detailed probing of subsurface tissue structures with resolution on the order of microns, it is associated with a limited field of view, on the order of millimeters, and thus screening of large organs is not very practical because involves the time-consuming analysis of very large data sets. The use of a guidance tool, like enhanced contrast fluorescence imaging, can help to highlight the presence of suspicious lesions. Therefore, OCT imaging can be performed only on the suspicious lesions as a confirmatory tool. A detailed description of this technology and preliminary results on excised colon tissue samples are presented.

Original languageEnglish (US)
Title of host publicationNovel Techniques in Microscopy, NTM 2009
StatePublished - 2009
Externally publishedYes
EventNovel Techniques in Microscopy, NTM 2009 - Vancouver, Canada
Duration: Apr 26 2009Apr 30 2009

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceNovel Techniques in Microscopy, NTM 2009

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics


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