TY - JOUR
T1 - Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.
AU - Bravo, Roberto
AU - Parra, Valentina
AU - Gatica, Damián
AU - Rodriguez, Andrea E.
AU - Torrealba, Natalia
AU - Paredes, Felipe
AU - Wang, Zhao
AU - Zorzano, Antonio
AU - Hill, Joseph A
AU - Jaimovich, Enrique
AU - Quest, Andrew F G
AU - Lavandero, Sergio
PY - 2013
Y1 - 2013
N2 - The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.
AB - The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.
KW - Calcium
KW - Endoplasmic reticulum
KW - ER stress
KW - Metabolism
KW - Organelle dynamics
KW - Pathology
KW - Unfolded protein response
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U2 - 10.1016/B978-0-12-407704-1.00005-1
DO - 10.1016/B978-0-12-407704-1.00005-1
M3 - Article
C2 - 23317820
AN - SCOPUS:84872375449
SN - 1937-6448
VL - 301
SP - 215
EP - 290
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
ER -