Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns

J. Wells Logan, Elizabeth N. Allred, Raina N. Fichorova, Stephen Engelke, Olaf Dammann, Alan Leviton, Kathleen Lee, Anne McGovern, Jill Gambardella, Susan Ursprung, Ruth Blomquist, Bhavesh Shah, Karen Christianson, Camilia R. Martin, Linda J. Van Marter, Robert M. Insoft, Jennifer G. Wilson, Maureen Pimental, Cynthia Cole, John M. FiasconeJanet Madden, Ellen Nylen, Anne Furey, Francis Bednarek, Mary Naples, Beth Powers, Richard Ehrenkranz, Joanne Williams, Elaine Romano, T. Michael O'Shea, Debbie Gordon, Teresa Harold, Stephen C. Engelke, Sherry Moseley, Donna Pare, Carl Bose, Gennie Bose, Mariel Poortenga, Dinah Sutton, Carolyn Solomon, Nigel Paneth, Padmani Karna, Madeleine Lenski, Michael D. Schreiber, Grace Yoon, Daniel Batton, Beth Kring, Ken Wood, Deborah Hirtz

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Introduction: Erythropoietin, a pluripotent glycoprotein essential for erythropoiesis, fetal growth, and development, has recently been implicated in innate immune regulation. Data from the ELGAN Study allowed us to evaluate relationships between endogenous erythropoietin and 25 inflammation-related proteins in extremely premature newborns. Methods: We measured the concentrations of 25 inflammation-related proteins and of erythropoietin in blood spots collected on postnatal days 1, 7, and 14 from 936 infants born before 28. weeks gestation. We calculated the odds that infants with an inflammation-related protein in the highest quartile for gestational age and collection day had an erythropoietin concentration in the highest or lowest quartile. Results: The proportion of children with inflammation-associated protein concentrations in the top quartile tended to increase monotonically with increasing quartile of EPO concentrations on 2 of the 3. days assessed. To a large extent, on each of the 3. days assessed, the odds ratios for an erythropoietin concentration in the top quartile were significantly elevated among those with an inflammation-related protein concentration in the top quartile. Conclusions: Our findings suggest that in very preterm newborns, circulating levels of endogenous erythropoietin vary significantly with circulating levels of inflammation-related proteins. Elevation of endogenous erythropoietin might not be an epiphenomenon, but instead might contribute to subsequent events, by either promoting or reducing inflammation, or by promoting an anti-injury or repair capability.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
Issue number1
StatePublished - Sep 2014


  • Acute-phase
  • Cytokine
  • Infant
  • Premature
  • Protein

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Biochemistry
  • Immunology and Allergy
  • Immunology


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