Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9

Nawal Bendris; Sandra L. Schmid

doi:10.1016/j.tcb.2016.11.001

Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9

Nawal Bendris, Sandra L. Schmid

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.

Original language	English (US)
Pages (from-to)	189-200
Number of pages	12
Journal	Trends in Cell Biology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.tcb.2016.11.001
State	Published - Mar 1 2017

Keywords

RhoGTPase
actin
cancer
cell motility
inflammation
invadosome
mitosis

ASJC Scopus subject areas

Cell Biology

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10.1016/j.tcb.2016.11.001

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abstract = "Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.",

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N2 - Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.

AB - Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.

KW - RhoGTPase

KW - actin

KW - cancer

KW - cell motility

KW - inflammation

KW - invadosome

KW - mitosis

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JO - Trends in Cell Biology

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ER -

Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9

Abstract

Keywords

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