Endocrine response after gamma knife-based stereotactic radiosurgery for secretory pituitary adenoma

Brent A. Tinnel, Mark A. Henderson, Thomas C. Witt, Achilles J. Fakiris, Robert M. Worth, Paul M. Des Rosiers, James W. Edmondson, Robert D. Timmerman, Simon S. Lo

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Purpose: To examine treatment outcomes of Gamma Knife-based stereotactic radiosurgery (GK-based SRS) for secretory pituitary adenomas. Materials and Methods: 25 patients were treated with GK-based SRS for secretory pituitary adenomas with ≥12 months of follow-up. Results: For prolactinomas, 2 of 4 patients (50%) showed normalization of serum prolactin at a mean time of 18 months. One of 4 had a ≥50% decrease but still abnormal prolactin levels. For adrenocorticotrophic hormone-secreting tumors, 6 of 12 patients (50%) showed normalization of their endocrine levels at a median of 10 months. An additional 2 (17%) had a ≥50% decrease. For growth hormone-secreting tumors, 4 of 9 patients (44%) showed normalization of endocrine levels at a median time of 30 months. Two patients (22%) had ≥50% lower but abnormal endocrine levels. Conclusion: GK-based SRS provides a reasonable rate of endocrine normalization of secretory pituitary adenoma. The time to endocrine response is shorter than reported for fractionated external beam radiotherapy. There is a low risk of optic neuropathy.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalStereotactic and Functional Neurosurgery
Issue number5
StatePublished - Oct 2008


  • Endocrine response
  • Gamma Knife
  • Secretory pituitary adenoma
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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