TY - GEN
T1 - Enabling High-Resolution (~2 mm or better) Brain Imaging with a Standard Clinical Whole-Body PET
T2 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
AU - Wang, Kai
AU - Wang, Jing
AU - Shao, Yiping
N1 - Funding Information:
Manuscript received December 1, 2021. This work was supported by the National Institutes of Health under Grant No. 1R01CA218402, 1R01EB019438, and R21 CA187717.
Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - A new method of achieving high-resolution imaging (~2 mm or better) with a standard clinical whole-body PET (WB-PET) has been proposed and investigated. The basic concept of this new method, dubbed as hybrid WB-PET imaging, is to convert the low-resolution projection data acquired by a WB-PET to high-resolution projection data through a mutual relationship between the low-resolution and high-resolution data, and such mutual relationship can be obtained through a preset calibration process with a set of dual low-resolution and high-resolution data acquisitions. The initial 2D simulation feasibility study has been conducted. The results show that the hybrid WB-PET can achieve ~1.1 mm spatial resolution compared to the 2.8 mm spatial resolution acquired by the standard WB-PET imaging under the ideal configuration and using an iterative image reconstruction. Although there are many remaining technical challenges to be investigated, if it can be achieved, hybrid WB-PET would transform the neuro-imaging study by using an existing WB-PET to achieve both high-resolution and high-sensitivity brain PET imaging (and possibly for other specific organ high-resolution imaging as well), which could have significant impact to improving PET/CT image based diagnosis and therapy guidance and even open the door for many new clinical research and applications.
AB - A new method of achieving high-resolution imaging (~2 mm or better) with a standard clinical whole-body PET (WB-PET) has been proposed and investigated. The basic concept of this new method, dubbed as hybrid WB-PET imaging, is to convert the low-resolution projection data acquired by a WB-PET to high-resolution projection data through a mutual relationship between the low-resolution and high-resolution data, and such mutual relationship can be obtained through a preset calibration process with a set of dual low-resolution and high-resolution data acquisitions. The initial 2D simulation feasibility study has been conducted. The results show that the hybrid WB-PET can achieve ~1.1 mm spatial resolution compared to the 2.8 mm spatial resolution acquired by the standard WB-PET imaging under the ideal configuration and using an iterative image reconstruction. Although there are many remaining technical challenges to be investigated, if it can be achieved, hybrid WB-PET would transform the neuro-imaging study by using an existing WB-PET to achieve both high-resolution and high-sensitivity brain PET imaging (and possibly for other specific organ high-resolution imaging as well), which could have significant impact to improving PET/CT image based diagnosis and therapy guidance and even open the door for many new clinical research and applications.
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U2 - 10.1109/NSS/MIC44867.2021.9875884
DO - 10.1109/NSS/MIC44867.2021.9875884
M3 - Conference contribution
AN - SCOPUS:85139142934
T3 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
BT - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
A2 - Tomita, Hideki
A2 - Nakamura, Tatsuya
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 16 October 2021 through 23 October 2021
ER -