Emerging roles for myoglobin in the heart

Daniel J. Garry; Shane B. Kanatous; Pradeep P A Mammen

doi:10.1016/S1050-1738(02)00256-6

Emerging roles for myoglobin in the heart

Daniel J. Garry, Shane B. Kanatous, Pradeep P A Mammen

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle. Transgenic and gene disruption technologies have been utilized to produce mice that lack Mb. Studies utilizing these transgenic mouse models support the notion that Mb may have multiple, diverse functions in the heart. Future studies using these emerging technologies will further enhance the understanding of the role of Mb and other hemoproteins in cardiovascular biology.

Original language	English (US)
Pages (from-to)	111-116
Number of pages	6
Journal	Trends in Cardiovascular Medicine
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/S1050-1738(02)00256-6
State	Published - Apr 2003

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S1050-1738(02)00256-6

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title = "Emerging roles for myoglobin in the heart",

abstract = "Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle. Transgenic and gene disruption technologies have been utilized to produce mice that lack Mb. Studies utilizing these transgenic mouse models support the notion that Mb may have multiple, diverse functions in the heart. Future studies using these emerging technologies will further enhance the understanding of the role of Mb and other hemoproteins in cardiovascular biology.",

author = "Garry, {Daniel J.} and Kanatous, {Shane B.} and Mammen, {Pradeep P A}",

note = "Funding Information: The authors thank Drs. R. Sanders Williams, Rhonda Bassel-Duby, and Annette Meeson for helpful discussions throughout the course of these studies. They also acknowledge funding support from the National Institutes of Health (HL63788) and the Donald W. Reynolds Foundation. ",

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AU - Kanatous, Shane B.

AU - Mammen, Pradeep P A

N1 - Funding Information: The authors thank Drs. R. Sanders Williams, Rhonda Bassel-Duby, and Annette Meeson for helpful discussions throughout the course of these studies. They also acknowledge funding support from the National Institutes of Health (HL63788) and the Donald W. Reynolds Foundation.

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N2 - Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle. Transgenic and gene disruption technologies have been utilized to produce mice that lack Mb. Studies utilizing these transgenic mouse models support the notion that Mb may have multiple, diverse functions in the heart. Future studies using these emerging technologies will further enhance the understanding of the role of Mb and other hemoproteins in cardiovascular biology.

AB - Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle. Transgenic and gene disruption technologies have been utilized to produce mice that lack Mb. Studies utilizing these transgenic mouse models support the notion that Mb may have multiple, diverse functions in the heart. Future studies using these emerging technologies will further enhance the understanding of the role of Mb and other hemoproteins in cardiovascular biology.

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Emerging roles for myoglobin in the heart

Abstract

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