Emerging Role of ISG15 in Antiviral Immunity

Brian Skaug, Zhijian J. Chen

Research output: Contribution to journalShort surveypeer-review

173 Scopus citations


Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
Issue number2
StatePublished - Oct 15 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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