Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice

Medicine & Life Sciences

• Calcium-Calmodulin-Dependent Protein Kinase Type 2 100%
• Clustered Regularly Interspaced Short Palindromic Repeats 90%
• Heart Failure 57%
• Constriction 27%
• Cardiac Myocytes 19%
• Adenine 16%
• Heart Diseases 11%
• Fibrosis 10%
• Gene Editing 8%
• Apoptosis 8%
• Fura-2 8%
• DNA Nucleotidylexotransferase 8%
• Induced Pluripotent Stem Cells 8%
• Germ-Line Mutation 8%
• RNA Sequence Analysis 8%
• Human Genome 7%
• Mortality 7%
• Adrenergic Agents 6%
• High-Throughput Nucleotide Sequencing 6%
• Cardiac Arrhythmias 6%
• Echocardiography 6%
• Microscopy 5%
• Protein Isoforms 5%
• Histology 5%
• Homeostasis 5%
• Cardiovascular Diseases 5%
• Staining and Labeling 4%
• Gene Expression 4%
• Morbidity 4%
• Safety 4%
• Enzymes 3%
• Therapeutics 3%
• Genes 2%