Elevated mutation rates in the germline of Polκ mutant male mice

Karen L A Burr, Susana Velasco-Miguel, Venkata S. Duvvuri, Lisa D. McDaniel, Errol C. Friedberg, Yuri E. Dubrova

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polκ-/-) deficient mice. The spontaneous mutation rate in homozygous Polκ-/- males was significantly higher than in isogenic wild-type mice (Polκ+/+), but the ESTR mutation spectrum in Polκ-/- animals did not differ from that in Polκ+/+ males. We suggest that compromised translesion synthesis in Polκ-/- mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.

Original languageEnglish (US)
Pages (from-to)860-862
Number of pages3
JournalDNA repair
Issue number7
StatePublished - Jul 13 2006


  • DNA polymerase kappa
  • Expanded simple tandem repeat loci
  • Germline mutation
  • Mice

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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