Elevated mean platelet volume is associated with silent cerebral infarction

B. Li, X. Liu, Z. G. Cao, Y. Li, T. M. Liu, R. T. Wang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: The presence of silent cerebral infarction (SCI) increases the risk of transient ischaemia attack, symptomatic stroke, cardiovascular disease and dementia. Mean platelet volume (MPV) is a surrogate marker of activated platelets and is considered a link between inflammation and thrombosis. In addition, MPV is a risk predictor for cardiovascular disease, stroke and overall vascular mortality. Aims: The purpose of the study was to assess the MPV levels in SCI patients. Methods: A cross-sectional study was conducted to evaluate the association between MPV and SCI in 2215 subjects (1385 men and 830 women). Results: The participants with SCI had higher MPV levels than those without SCI (10.4 ± 1.3fL vs. 9.2 ± 1.2fL; P < 0.001). Moreover, the subjects with a high MPV had a higher prevalence of SCI. Multivariate logistic regression analyses revealed that the odds ratios and 95% confidence intervals for SCI according to MPV quartiles were 1.000, 2.131 (1.319-3.444), 3.015 (1.896-4.794), 7.822 (4.874-12.554) respectively (P < 0.001). Conclusion: MPV is a novel index for SCI regardless of classical cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalInternal Medicine Journal
Issue number7
StatePublished - Jul 2014


  • Atherosclerosis
  • Mean platelet volume
  • Platelet activation
  • Risk factor
  • Silent cerebral infarction

ASJC Scopus subject areas

  • Internal Medicine


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