Electrical remodeling in cardiac hypertrophy

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


In recent years, electrical remodeling has emerged as an important pathophysiologic mechanism in many types of cardiac pathology. Because clinical heart disease often involves both hypertrophic and failure phenotypes, identification of disease-specific mechanisms is essential. This review focuses on mechanisms of electrical remodeling in cardiac hypertrophy, emphasizing transmembrane Ca2+ fluxes and Ca2+-responsive signaling pathways. Where information is available, the remodeling of hypertrophy is contrasted with what is known about heart failure.

Original languageEnglish (US)
Pages (from-to)316-322
Number of pages7
JournalTrends in Cardiovascular Medicine
Issue number8
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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