@article{8bd9417314b34c7a9d40e1fa68a3dca6,
title = "Effects of secretin on insulin and glucagon in portal and peripheral blood in man.",
author = "J. Dupr{\'e} and L. Rojas and White, {J. J.} and Unger, {Roger H} and Beck, {J. C.}",
note = "Funding Information: SUMMARY The results indicate that, in anaesthetised dogs, endo- portal injection of secretin-containing crude extract of hog duodenal mucosa is followed within 180 seconds by a more than threefold rise in mean pancreaticoduodenal- vein plasma-insulin concentration. This rise appears not to be the result of a change in pancreatic blood-flow. Purified secretin gave similar results, suggesting that it was the active component of the crude extract. The response of insulin secretion to secretin is not accom- panied by arterial hyperglycaemia and, in this respect, as well as in respect to its more rapid onset, differs from the insulin response to glucagon. This study was supported by U.S. Public Health Service grant NIH-5-R01-AM02700-08 and by the Upjohn Company, Kalama- zoo, Michigan, and the Ames Company, Inc., Elkhart, Indiana. Requests for reprints should be sent to Dr. R. H. Unger, Veterans Administration Hospital, 4500 S. Lancaster Road, Dallas, Texas 75216.",
year = "1966",
month = jul,
day = "2",
doi = "10.1016/s0140-6736(66)91750-8",
language = "English (US)",
volume = "288",
pages = "26--27",
journal = "Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7453",
}