Effects of obesity on the oxygen cost of breathing in children

Dharini M. Bhammar; Tony G. Babb

doi:10.1016/j.resp.2020.103591

Effects of obesity on the oxygen cost of breathing in children

Dharini M. Bhammar, Tony G. Babb

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3 Scopus citations

Abstract

The objective of this study was to examine the effects of obesity on the oxygen (O₂) cost of breathing using the eucapnic voluntary hyperpnea (EVH) technique in 10- and 11-year-old children. Seventeen children (8 without and 9 with obesity) underwent EVH trials at two levels of ventilation for assessing the O₂ cost of breathing (slope of oxygen uptake, V˙O₂ vs. minute ventilation) and a dual energy x-ray absorptiometry scan. Resting and EVH V˙O₂ was higher in children with obesity when compared with children without obesity (P = 0.0096). The O₂ cost of breathing did not statistically differ between children without (2.09 ± 0.46 mL/L) and with obesity (2.08 ± 0.64 mL/L, P = 0.99), but the intercept was significantly greater in children with obesity. Chest mass explained 85 % of the variance in resting V˙O₂ in children with obesity. Higher resting energy requirements, attributable to increased chest mass, can increase the absolute metabolic costs of exercise and hyperpnea in children with obesity.

Original language	English (US)
Article number	103591
Journal	Respiratory Physiology and Neurobiology
Volume	285
DOIs	https://doi.org/10.1016/j.resp.2020.103591
State	Published - Mar 2021

Keywords

Pediatric obesity
Resting oxygen uptake
Ventilatory load
Work of breathing

ASJC Scopus subject areas

Neuroscience(all)
Physiology
Pulmonary and Respiratory Medicine

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10.1016/j.resp.2020.103591

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title = "Effects of obesity on the oxygen cost of breathing in children",

abstract = "The objective of this study was to examine the effects of obesity on the oxygen (O2) cost of breathing using the eucapnic voluntary hyperpnea (EVH) technique in 10- and 11-year-old children. Seventeen children (8 without and 9 with obesity) underwent EVH trials at two levels of ventilation for assessing the O2 cost of breathing (slope of oxygen uptake, V˙O2 vs. minute ventilation) and a dual energy x-ray absorptiometry scan. Resting and EVH V˙O2 was higher in children with obesity when compared with children without obesity (P = 0.0096). The O2 cost of breathing did not statistically differ between children without (2.09 ± 0.46 mL/L) and with obesity (2.08 ± 0.64 mL/L, P = 0.99), but the intercept was significantly greater in children with obesity. Chest mass explained 85 % of the variance in resting V˙O2 in children with obesity. Higher resting energy requirements, attributable to increased chest mass, can increase the absolute metabolic costs of exercise and hyperpnea in children with obesity.",

keywords = "Pediatric obesity, Resting oxygen uptake, Ventilatory load, Work of breathing",

author = "Bhammar, {Dharini M.} and Babb, {Tony G.}",

note = "Funding Information: This research was supported by NIH R01 HL136643, Texas Health Presbyterian Hospital Dallas, King Charitable Foundation Trust, and unrestricted funds from Dr. Pepper Snapple. The sponsors had no input in the development of the research or manuscript. We would like to thank Jonathon Stickford, Vipa Bernhardt, J. Todd Bassett, Rubria Marines-Price, Maria C. Roman, Andreas Kreutzer, Joseph Genovese, Jessica Alcala, and Raksa B. Moran who have helped with data collection. Funding Information: This research was supported by NIH R01 HL136643, Texas Health Presbyterian Hospital Dallas , King Charitable Foundation Trust , and unrestricted funds from Dr. Pepper Snapple . The sponsors had no input in the development of the research or manuscript. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

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N2 - The objective of this study was to examine the effects of obesity on the oxygen (O2) cost of breathing using the eucapnic voluntary hyperpnea (EVH) technique in 10- and 11-year-old children. Seventeen children (8 without and 9 with obesity) underwent EVH trials at two levels of ventilation for assessing the O2 cost of breathing (slope of oxygen uptake, V˙O2 vs. minute ventilation) and a dual energy x-ray absorptiometry scan. Resting and EVH V˙O2 was higher in children with obesity when compared with children without obesity (P = 0.0096). The O2 cost of breathing did not statistically differ between children without (2.09 ± 0.46 mL/L) and with obesity (2.08 ± 0.64 mL/L, P = 0.99), but the intercept was significantly greater in children with obesity. Chest mass explained 85 % of the variance in resting V˙O2 in children with obesity. Higher resting energy requirements, attributable to increased chest mass, can increase the absolute metabolic costs of exercise and hyperpnea in children with obesity.

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Effects of obesity on the oxygen cost of breathing in children

Abstract

Keywords

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