Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat

Sam Castellani; A. James Giannini; Perrie M. Adams

doi:10.1007/BF00470593

Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat

Sam Castellani, A. James Giannini, Perrie M. Adams

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 μg/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 μg/kg) at 2.0 mg/kg and inhibited by metenkephalin (40 μg/kg) and morphine (10 mg/kg) at 4.0 and 6.0 mg/kg PCP. Locomotor activity was increased by morphine (5 mg/kg) at 2 mg/kg PCP. These results suggest an involvement of central opiate receptor mechanisms in the mediation of PCP-induced behaviors in the rat.

Original language	English (US)
Pages (from-to)	76-80
Number of pages	5
Journal	Psychopharmacology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1007/BF00470593
State	Published - Mar 1 1982

Keywords

Ataxia
Locomotor activity
Metenkephalin
Morphine
Naloxone
Phencyclidine
Stereotypy

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00470593

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title = "Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat",

abstract = "The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 μg/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 μg/kg) at 2.0 mg/kg and inhibited by metenkephalin (40 μg/kg) and morphine (10 mg/kg) at 4.0 and 6.0 mg/kg PCP. Locomotor activity was increased by morphine (5 mg/kg) at 2 mg/kg PCP. These results suggest an involvement of central opiate receptor mechanisms in the mediation of PCP-induced behaviors in the rat.",

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KW - Stereotypy

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Effects of naloxone, metenkephalin, and morphine on phencyclidine-induced behavior in the rat

Abstract

Keywords

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