Abstract
The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 μg/kg) and morphine (5 and 10 mg/kg) increased ataxia at the 4.0 and 6.0 mg/kg PCP doses. Stereotypy was altered by the opiates in a dose-dependent manner; enhanced by metenkephalin (40 μg/kg) at 2.0 mg/kg and inhibited by metenkephalin (40 μg/kg) and morphine (10 mg/kg) at 4.0 and 6.0 mg/kg PCP. Locomotor activity was increased by morphine (5 mg/kg) at 2 mg/kg PCP. These results suggest an involvement of central opiate receptor mechanisms in the mediation of PCP-induced behaviors in the rat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 76-80 |
| Number of pages | 5 |
| Journal | Psychopharmacology |
| Volume | 78 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1982 |
Keywords
- Ataxia
- Locomotor activity
- Metenkephalin
- Morphine
- Naloxone
- Phencyclidine
- Stereotypy
ASJC Scopus subject areas
- Pharmacology