Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase

Tetsuya Kakuma, Young H Lee, Roger H Unger

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Leptin, troglitazone, and high fat feeding profoundly influence the lipid content of various tissues. To determine if they affect the expression of stearoyl CoA desaturase (SCD)-1 and -2, their mRNA was measured in livers of normal, hyperleptinemic, troglitazone-treated, and fat-fed rats. Hyperleptinemia, which reduces tissue TG by downregulating lipogenic enzymes and upregulating fatty acid oxidation, lowered SCD-1 96% below controls and reduced SCD-2 slightly. By contrast, hepatic SCD-1 mRNA of leptin-resistant fa/fa rats was five times wild-type controls, but SCD-2 mRNA was 66% lower. High fat feeding lowered SCD-1 by 80%, possibly by inducing hyperleptinemia. Troglitazone treatment, which reduces nonadipose tissue TG of fa/fa rats without down-regulating lipogenic enzymes, raised SCD-2 13-fold but lowered SCD-1 by 25%. The findings suggest that leptin controls SCD-1 expression and that troglitazone's antilipotoxic action may involve SCD-2 upregulation.

Original languageEnglish (US)
Pages (from-to)1259-1263
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number5
StatePublished - 2002


  • Ceramide
  • Diet-induced obesity
  • Leptin
  • Lipotoxicity
  • Stearoyl CoA desaturase
  • Thiazolidinediones
  • Troglitazone

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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