Effects of in vivo cocaine administration on human platelet aggregation

Christian M. Heesch, Brian H. Negus, Manfred Steiner, Richard W. Snyder, Donald D. McIntire, Paul A. Grayburn Md, Joy Ashcraft, José A. Hernández, Eric J. Eichhorn

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalAmerican Journal of Cardiology
Issue number2
StatePublished - Jul 15 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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