Effects of hyperbaric hyperoxia on cardiac and regional hemodynamics in conscious dogs

James M. Berry, Marie Francois Doursout, Bruce D. Butler

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: Although evidence of systemic vasoconstriction has been reported both in animal models and in humans, the regional hemodynamic effects of hyperbaric hyperoxia have not been well characterized. Methods: In the present study, we report the effects of hyperoxia (normobaric and hyperbaric) on simultaneous measurements of cardiac and regional hemodynamics in the chronically instrumented conscious dog. Results: Hyperbaric hyperoxia (202 kPa) produced significant decreases in heart rate (12%) and cardiac output (20%) and a significant increase in systemic vascular resistance (30%). Carotid artery blood flow decreased significantly (18%) whereas coronary, hepatic, renal and roesenteric flows remained unchanged. Conclusions: Our data show that the hyperoxic vasoconstriction is limited to the cerebral and peripheral vascular beds. Additionally, blood flow to major organs is well preserved in the face of hyperoxia-induced decreases in cardiac output. Consequently, we postulate that a redistribution of blood flow from peripheral vascular beds (e.g., skin, muscle, bone) to major organs occurs during hyperbaric hyperoxia.

Original languageEnglish (US)
Pages (from-to)761-765
Number of pages5
JournalAviation Space and Environmental Medicine
Issue number8
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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