Effects of heterologous transplantation of a mouse plasmacytoma. I. Runting syndrome secondary to malignant tumors

Eugene P. Frenkel, Donald R. Korst, Giovanni Raccuglia

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Heterologous transplantation studies were performed with transfer of a X5563 plasma cell (myeloma) tumor of C3H mice to normal Sprague-Dawley rats. The animals were followed, by serial serum protein electrophoretic patterns. Direct neonatal tumor transplantation was unsuccessful; neither electrophoretic changes nor "runting syndrome" was produced. There was no runting in the spleen-conditioned group in which tumor was not subsequently transplanted, in the direct tumor transplant group, in the saline neonatally conditioned group (which also received tumor transplantation at 42 to 47 days), or in the saline or spleen conditioned rats which were subsequently given C3H thigh muscle transplants. Transient increase in α1, α2, and β globulins were seen in 66.66 per cent of direct transfer animals, 50 per cent of the saline conditioned animals, and 54.3 per cent of the spleen conditioned animals. The change, which occurred approximately 4 weeks after the tumor transplantation and persisted for about 3 weeks, is believed to represent a pattern of tumor rejection by the host. Neonatal conditioning of the rats with spleen homogenates from normal CSH mice did not produce runting or protein changes. Tumor transplantation with X5563 tissue was performed at 48 to 47 days with 45.7 per cent takes. Classical "runting syndrome" developed in all of these animals. Gel diffusion studies demonstrated that the globulins present in these rat "runts" had their origin largely from X5563 globulins. Although clinical and laboratory evidence supported the fact of a tumor take, no specific tumor could be identified at postmortem examination of these animals. It is possible that the course of events in these animals in some way modified this tumor.

Original languageEnglish (US)
Pages (from-to)81-94
Number of pages14
JournalThe Journal of laboratory and clinical medicine
Issue number1
StatePublished - Jan 1962

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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