Effects of Helicobacter pylori gastritis on gastric secretion in healthy human beings

Mark Feldman, Byron Cryer, Edward Lee

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Helicobacter pylori gastritis is common, but effects on gastric secretion are not well understood. We measured basal and pentagastrin- stimulated gastric acidity, pepsin activity, and fluid output, as well as serum gastrin concentrations and H. pylori antibody levels, before and after treatment of H. pylori gastritis in 28 men and women. Subjects were studied before and 1 and 3 mo after a course of bismuth, metronidazole, and tetracycline. Elimination of H. pylori gastritis, accomplished in 14 subjects, increased basal and pentagastrin-stimulated gastric acidity (by 15 meq/l) and basal acid output significantly (by 2.1 meq/h 1 mo after therapy). Elimination of H. pylori had an opposite effect on pepsin secretion, significantly decreasing pepsin output by 30%. Elimination of H. pylori significantly reduced nonparietal fluid output by 35%, without affecting fluid output from parietal cells. Serum gastrin and H. pylori antibody levels declined significantly after elimination of H. pylori. None of these changes was observed in 14 subjects whose H. pylori gastritis was resistant to antimicrobial therapy. In summary, eradication of H. pylori infection increases gastric acidity by reducing nonparietal gastric secretion from peptic and other cells.

Original languageEnglish (US)
Pages (from-to)G1011-G1017
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number6 37-6
StatePublished - Jun 1998


  • Gastric acidity
  • Nonparietal secretion
  • Pentagastrin
  • Pepsin activity
  • Serum gastrin

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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