Abstract
A synthetic analog of ethinyltestosterone, Danazol, has been used clinically for the treatment of immune thrombocytopenia. We investigated the effects of Danazol on thrombopoiesis in normal rats. Though 4-week treatment by Danazol slightly enhanced the DNA synthesizing enzyme activities and the number of S-phase cells in bone marrow and spleen, the number of megakaryocytes and thrombocytes were not increased in bone marrow and peripheral blood, respectively. These findings suggest that Danazol treatment will not induce thrombosis with thrombocytosis in normal human beings and animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1003-1005 |
| Number of pages | 3 |
| Journal | In Vivo |
| Volume | 8 |
| Issue number | 6 |
| State | Published - 1994 |
Keywords
- Danazol
- Rat
- Thrombopoiesis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cancer Research
- Pharmacology