Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin

Hussein Y. Naim; Bilal Amarneh; Nicholas T. Ktistakis; Michael G. Roth

doi:10.1128/jvi.66.12.7585-7588.1992

Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin

Hussein Y. Naim, Bilal Amarneh, Nicholas T. Ktistakis, Michael G. Roth

Research output: Contribution to journal › Comment/debate › peer-review

52 Scopus citations

Abstract

Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

Original language	English (US)
Pages (from-to)	7585-7588
Number of pages	4
Journal	Journal of virology
Volume	66
Issue number	12
DOIs	https://doi.org/10.1128/jvi.66.12.7585-7588.1992
State	Published - 1992

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.66.12.7585-7588.1992

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title = "Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin",

abstract = "Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.",

author = "Naim, {Hussein Y.} and Bilal Amarneh and Ktistakis, {Nicholas T.} and Roth, {Michael G.}",

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AU - Naim, Hussein Y.

AU - Amarneh, Bilal

AU - Ktistakis, Nicholas T.

AU - Roth, Michael G.

PY - 1992

Y1 - 1992

N2 - Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

AB - Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

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DO - 10.1128/jvi.66.12.7585-7588.1992

M3 - Comment/debate

C2 - 1433532

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SN - 0022-538X

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JO - Journal of virology

JF - Journal of virology

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ER -

Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin

Abstract

ASJC Scopus subject areas

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