Effectiveness of a six‐drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

Bruce M. Camitta; Stephen J. Lauer; James T. Casper; Phyllis A. Kirchner; Larry E. Kun; Herbert W. Oechler; Stuart E. Adair

doi:10.1002/1097-0142(19850815)56:4<738::AID-CNCR2820560406>3.0.CO;2-O

Effectiveness of a six‐drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

Bruce M. Camitta, Stephen J. Lauer, James T. Casper, Phyllis A. Kirchner, Larry E. Kun, Herbert W. Oechler, Stuart E. Adair

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six‐drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T‐cell lymphoblastic lymphomas.

Original language	English (US)
Pages (from-to)	738-741
Number of pages	4
Journal	Cancer
Volume	56
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(19850815)56:4<738::AID-CNCR2820560406>3.0.CO;2-O
State	Published - Aug 15 1985

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19850815)56:4<738::AID-CNCR2820560406>3.0.CO;2-O

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title = "Effectiveness of a six‐drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children",

abstract = "Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six‐drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T‐cell lymphoblastic lymphomas.",

author = "Camitta, {Bruce M.} and Lauer, {Stephen J.} and Casper, {James T.} and Kirchner, {Phyllis A.} and Kun, {Larry E.} and Oechler, {Herbert W.} and Adair, {Stuart E.}",

year = "1985",

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T1 - Effectiveness of a six‐drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

AU - Camitta, Bruce M.

AU - Lauer, Stephen J.

AU - Casper, James T.

AU - Kirchner, Phyllis A.

AU - Kun, Larry E.

AU - Oechler, Herbert W.

AU - Adair, Stuart E.

PY - 1985/8/15

Y1 - 1985/8/15

N2 - Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six‐drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T‐cell lymphoblastic lymphomas.

AB - Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six‐drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T‐cell lymphoblastic lymphomas.

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Effectiveness of a six‐drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

Abstract

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