Effective Use of Dupilumab in Managing Systemic Allergic Contact Dermatitis

Shyam R. Joshi, David A. Khan

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Allergic contact dermatitis to metals has become increasingly recognized in patients with endovascular implants. The ACD can lead to in-stent restenosis as well as a prominent eczematous reaction overlying the implant, often necessitating its removal. We present a case of refractory allergic contact dermatitis to nickel in a 44-year-old man with numerous endovascular stents and vascular clips. He developed numerous adverse effects of systemic therapy to manage his symptoms including recurrent infections leading to frequent hospitalizations. He was effectively transitioned to dupilumab, a monoclonal antibody against the IL-4α subunit currently approved by the Food and Drug Administration in the management of atopic dermatitis, with an improvement in symptoms and a reduction in infection rate.

Original languageEnglish (US)
Pages (from-to)282-284
Number of pages3
Issue number5
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology


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