Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression

Rafae A. Wathra; Benoit H. Mulsant; Zafiris J. Daskalakis; Jonathan Downar; Shawn M. McClintock; Sean M. Nestor; Tarek K. Rajji; Alisson P. Trevizol; Daniel M. Blumberger

doi:10.1192/bjp.2023.81

Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression

Rafae A. Wathra, Benoit H. Mulsant, Zafiris J. Daskalakis, Jonathan Downar, Shawn M. McClintock, Sean M. Nestor, Tarek K. Rajji, Alisson P. Trevizol, Daniel M. Blumberger

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is used for treatment of late-life depression. In the FOUR-D study, sequential bilateral theta-burst stimulation (TBS) had comparable remission rates to standard bilateral rTMS. Data were analysed from the FOUR-D trial to compare remission rates between two types of rTMS based on the number and class of prior medication trials. The remission rate was higher in participants with ≤1 previous trial (43.9%) than in participants with 2 previous trials (26.5%) or ≥3 previous trials (24.6%; χ² = 6.36, d.f. = 2, P = 0.04). Utilising rTMS earlier in late-life depression may lead to better outcomes.

Original language	English (US)
Pages (from-to)	504-506
Number of pages	3
Journal	British Journal of Psychiatry
Volume	223
Issue number	5
DOIs	https://doi.org/10.1192/bjp.2023.81
State	Published - Nov 19 2023

Keywords

Depression
geriatric
neurostimulation.
rTMS
theta burst

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1192/bjp.2023.81

Cite this

Wathra, R. A., Mulsant, B. H., Daskalakis, Z. J., Downar, J., McClintock, S. M., Nestor, S. M., Rajji, T. K., Trevizol, A. P., & Blumberger, D. M. (2023). Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression. British Journal of Psychiatry, 223(5), 504-506. https://doi.org/10.1192/bjp.2023.81

Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression. / Wathra, Rafae A.; Mulsant, Benoit H.; Daskalakis, Zafiris J. et al.
In: British Journal of Psychiatry, Vol. 223, No. 5, 19.11.2023, p. 504-506.

Research output: Contribution to journal › Article › peer-review

Wathra, RA, Mulsant, BH, Daskalakis, ZJ, Downar, J, McClintock, SM, Nestor, SM, Rajji, TK, Trevizol, AP & Blumberger, DM 2023, 'Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression', British Journal of Psychiatry, vol. 223, no. 5, pp. 504-506. https://doi.org/10.1192/bjp.2023.81

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abstract = "Repetitive transcranial magnetic stimulation (rTMS) is used for treatment of late-life depression. In the FOUR-D study, sequential bilateral theta-burst stimulation (TBS) had comparable remission rates to standard bilateral rTMS. Data were analysed from the FOUR-D trial to compare remission rates between two types of rTMS based on the number and class of prior medication trials. The remission rate was higher in participants with ≤1 previous trial (43.9%) than in participants with 2 previous trials (26.5%) or ≥3 previous trials (24.6%; χ² = 6.36, d.f. = 2, P = 0.04). Utilising rTMS earlier in late-life depression may lead to better outcomes.",

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AU - Mulsant, Benoit H.

AU - Daskalakis, Zafiris J.

AU - Downar, Jonathan

AU - McClintock, Shawn M.

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AB - Repetitive transcranial magnetic stimulation (rTMS) is used for treatment of late-life depression. In the FOUR-D study, sequential bilateral theta-burst stimulation (TBS) had comparable remission rates to standard bilateral rTMS. Data were analysed from the FOUR-D trial to compare remission rates between two types of rTMS based on the number and class of prior medication trials. The remission rate was higher in participants with ≤1 previous trial (43.9%) than in participants with 2 previous trials (26.5%) or ≥3 previous trials (24.6%; χ² = 6.36, d.f. = 2, P = 0.04). Utilising rTMS earlier in late-life depression may lead to better outcomes.

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Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression

Abstract

Keywords

ASJC Scopus subject areas

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