Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

B. Eggleston; M. Patience; S. Edwards; T. Adamkiewicz; G. R. Buchanan; S. C. Davies; R. Dickerhoff; S. Donfield; S. A. Feig; R. H. Giller; A. Haight; J. Horan; L. L. Hsu; N. Kamani; P. Lane; J. E. Levine; D. Margolis; T. B. Moore; K. Ohene-Frempong; R. Redding-Lallinger; I. A G Roberts; Z. R. Rogers; J. E. Sanders; J. P. Scott; B. Sleight; A. A. Thompson; K. M. Sullivan; M. C. Walters

doi:10.1111/j.1365-2141.2006.06486.x

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

B. Eggleston, M. Patience, S. Edwards, T. Adamkiewicz, G. R. Buchanan, S. C. Davies, R. Dickerhoff, S. Donfield, S. A. Feig, R. H. Giller, A. Haight, J. Horan, L. L. Hsu, N. Kamani, P. Lane, J. E. Levine, D. Margolis, T. B. Moore, K. Ohene-Frempong, R. Redding-LallingerI. A G Roberts, Z. R. Rogers, J. E. Sanders, J. P. Scott, B. Sleight, A. A. Thompson, K. M. Sullivan, M. C. Walters

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42 Scopus citations

Abstract

Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

Original language	English (US)
Pages (from-to)	673-676
Number of pages	4
Journal	British Journal of Haematology
Volume	136
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2006.06486.x
State	Published - Feb 2007

Keywords

Sickle cell anaemia
Transplantation

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2006.06486.x

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Eggleston, B., Patience, M., Edwards, S., Adamkiewicz, T., Buchanan, G. R., Davies, S. C., Dickerhoff, R., Donfield, S., Feig, S. A., Giller, R. H., Haight, A., Horan, J., Hsu, L. L., Kamani, N., Lane, P., Levine, J. E., Margolis, D., Moore, T. B., Ohene-Frempong, K., ... Walters, M. C. (2007). Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. British Journal of Haematology, 136(4), 673-676. https://doi.org/10.1111/j.1365-2141.2006.06486.x

Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. / Eggleston, B.; Patience, M.; Edwards, S. et al.
In: British Journal of Haematology, Vol. 136, No. 4, 02.2007, p. 673-676.

Research output: Contribution to journal › Article › peer-review

Eggleston, B, Patience, M, Edwards, S, Adamkiewicz, T, Buchanan, GR, Davies, SC, Dickerhoff, R, Donfield, S, Feig, SA, Giller, RH, Haight, A, Horan, J, Hsu, LL, Kamani, N, Lane, P, Levine, JE, Margolis, D, Moore, TB, Ohene-Frempong, K, Redding-Lallinger, R, Roberts, IAG, Rogers, ZR, Sanders, JE, Scott, JP, Sleight, B, Thompson, AA, Sullivan, KM & Walters, MC 2007, 'Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia', British Journal of Haematology, vol. 136, no. 4, pp. 673-676. https://doi.org/10.1111/j.1365-2141.2006.06486.x

Eggleston B, Patience M, Edwards S, Adamkiewicz T, Buchanan GR, Davies SC et al. Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. British Journal of Haematology. 2007 Feb;136(4):673-676. doi: 10.1111/j.1365-2141.2006.06486.x

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abstract = "Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.",

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AU - Ohene-Frempong, K.

AU - Redding-Lallinger, R.

AU - Roberts, I. A G

AU - Rogers, Z. R.

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AB - Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

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Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: Results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia

Abstract

Keywords

ASJC Scopus subject areas

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