TY - JOUR
T1 - Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity
AU - Chiao, Hsi
AU - Pelletier, S. William
AU - Desai, Haridutt K.
AU - Rebagay, Winona R.
AU - Caldwell, R. William
N1 - Funding Information:
Corresponding author. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. Tel. 706 721-3384, fax 706 721-6059. Supported by NIH grant HL-32562.
PY - 1995/9/5
Y1 - 1995/9/5
N2 - The diterpenoid alkaloid, lappaconitine, at a dose of 150 μg/kg (i.v.) increased cardiac vagal afferent nerve activity (16.2%) and reduced cardiac sympathetic efferent nerve activity (12.5%). A polar analog, N-deacetyllappaconitine, at this same dose, increased cardiac vagal afferent nerve activity (40%) and reduced cardiac sympathetic efferent nerve activity (23.5%). Both of these agents also reduced arterial blood pressure and heart rate. A larger dose of lappaconitine (300 μg/kg i.v.) produced the same changes in nerve activities and cardiac function as the lower dose. Two other structurally related agents, lycoctonine and aconine, failed to alter these variables in doses up to 300 μg/kg. These data suggest that certain diterpenoid alkaloids activate autonomic reflex receptors, including cardiac reflex receptors. The polar agent, N-deacetyllappaconitine, appears to be more effective on cardiac reflex receptors than the non-polar agent, lappaconitine. Such agents may be useful in the treatment of hypertension.
AB - The diterpenoid alkaloid, lappaconitine, at a dose of 150 μg/kg (i.v.) increased cardiac vagal afferent nerve activity (16.2%) and reduced cardiac sympathetic efferent nerve activity (12.5%). A polar analog, N-deacetyllappaconitine, at this same dose, increased cardiac vagal afferent nerve activity (40%) and reduced cardiac sympathetic efferent nerve activity (23.5%). Both of these agents also reduced arterial blood pressure and heart rate. A larger dose of lappaconitine (300 μg/kg i.v.) produced the same changes in nerve activities and cardiac function as the lower dose. Two other structurally related agents, lycoctonine and aconine, failed to alter these variables in doses up to 300 μg/kg. These data suggest that certain diterpenoid alkaloids activate autonomic reflex receptors, including cardiac reflex receptors. The polar agent, N-deacetyllappaconitine, appears to be more effective on cardiac reflex receptors than the non-polar agent, lappaconitine. Such agents may be useful in the treatment of hypertension.
KW - Autonomic nerve
KW - Blood pressure
KW - Diterpenoid alkaloid
KW - Heart rate
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U2 - 10.1016/0014-2999(95)00290-2
DO - 10.1016/0014-2999(95)00290-2
M3 - Article
C2 - 7498298
AN - SCOPUS:0029101896
SN - 0014-2999
VL - 283
SP - 103
EP - 106
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -