Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Madhvi Rajpurkar; Patricia Alcasabas; Indulekha Warrier; Rudolph P. Valentini; Nancy Fassinger; Daniel A C Frattarelli; Yaddanapudi Ravindranath

doi:10.1002/pbc.20844

Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Madhvi Rajpurkar, Patricia Alcasabas, Indulekha Warrier, Rudolph P. Valentini, Nancy Fassinger, Daniel A C Frattarelli, Yaddanapudi Ravindranath

Pediatrics

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5 Scopus citations

Abstract

All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

Original language	English (US)
Pages (from-to)	994-996
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	49
Issue number	7
DOIs	https://doi.org/10.1002/pbc.20844
State	Published - Dec 2007

Keywords

All trans retinoic acid
Promyelocyte leukemia
Renal failure

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.20844

Cite this

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abstract = "All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.",

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AU - Rajpurkar, Madhvi

AU - Alcasabas, Patricia

AU - Warrier, Indulekha

AU - Valentini, Rudolph P.

AU - Fassinger, Nancy

AU - Frattarelli, Daniel A C

AU - Ravindranath, Yaddanapudi

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AB - All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

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Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Abstract

Keywords

ASJC Scopus subject areas

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