Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Madhvi Rajpurkar; Patricia Alcasabas; Indulekha Warrier; Rudolph P. Valentini; Nancy Fassinger; Daniel A C Frattarelli; Yaddanapudi Ravindranath

doi:10.1002/pbc.20844

Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Madhvi Rajpurkar, Patricia Alcasabas, Indulekha Warrier, Rudolph P. Valentini, Nancy Fassinger, Daniel A C Frattarelli, Yaddanapudi Ravindranath

Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

Original language	English (US)
Pages (from-to)	994-996
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	49
Issue number	7
DOIs	https://doi.org/10.1002/pbc.20844
State	Published - Dec 1 2007

Keywords

All trans retinoic acid
Promyelocyte leukemia
Renal failure

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.20844

Cite this

@article{2fc17d31bbdf464d80e3577fe28329d7,

title = "Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure",

abstract = "All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.",

keywords = "All trans retinoic acid, Promyelocyte leukemia, Renal failure",

author = "Madhvi Rajpurkar and Patricia Alcasabas and Indulekha Warrier and Valentini, {Rudolph P.} and Nancy Fassinger and Frattarelli, {Daniel A C} and Yaddanapudi Ravindranath",

year = "2007",

month = dec,

day = "1",

doi = "10.1002/pbc.20844",

language = "English (US)",

volume = "49",

pages = "994--996",

journal = "Medical and Pediatric Oncology",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "7",

}

TY - JOUR

T1 - Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

AU - Rajpurkar, Madhvi

AU - Alcasabas, Patricia

AU - Warrier, Indulekha

AU - Valentini, Rudolph P.

AU - Fassinger, Nancy

AU - Frattarelli, Daniel A C

AU - Ravindranath, Yaddanapudi

PY - 2007/12/1

Y1 - 2007/12/1

N2 - All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

AB - All trans retinoic acid (ATRA) combined with chemotherapy has become the mainstay of treatment for patients with acute promyelocyte leukemia (APL). Renal dysfunction (RD) is commonly seen in patients with APL. We describe a patient with APL and multi-organ failure, who was on chronic veno-venous hemofiltration followed by hemodialysis (HD) and later peritoneal dialysis (PD), who received ATRA. ATRA levels were assessed as the body clearance of ATRA in children on HD and/or PD was unknown. Neither HD nor PD significantly affected ATRA levels, suggesting that dose modifications of ATRA may not be necessary for children with these forms of renal replacement therapy.

KW - All trans retinoic acid

KW - Promyelocyte leukemia

KW - Renal failure

UR - http://www.scopus.com/inward/record.url?scp=35648994252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35648994252&partnerID=8YFLogxK

U2 - 10.1002/pbc.20844

DO - 10.1002/pbc.20844

M3 - Article

C2 - 16609947

AN - SCOPUS:35648994252

SN - 1545-5009

VL - 49

SP - 994

EP - 996

JO - Medical and Pediatric Oncology

JF - Medical and Pediatric Oncology

IS - 7

ER -

Effect of dialysis on all trans retinoic acid levels in a child with acute promyelocytic leukemia and renal failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this