Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

Mark O. McCarron; C. J. Weir; K. W. Muir; K. L. Hoffmann; C. Graffagnino; J. A R Nicoll; K. R. Lees; M. J. Alberts

doi:10.1034/j.1600-0404.2003.01365.x

Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

Mark O. McCarron, C. J. Weir, K. W. Muir, K. L. Hoffmann, C. Graffagnino, J. A R Nicoll, K. R. Lees, M. J. Alberts

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62 Scopus citations

Abstract

Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

Original language	English (US)
Pages (from-to)	106-109
Number of pages	4
Journal	Acta Neurologica Scandinavica
Volume	107
Issue number	2
DOIs	https://doi.org/10.1034/j.1600-0404.2003.01365.x
State	Published - Feb 1 2003

Keywords

Apolipoprotein E
Intracerebral haemorrhage
Outcome
Survival

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1034/j.1600-0404.2003.01365.x

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title = "Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage",

abstract = "Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.",

keywords = "Apolipoprotein E, Intracerebral haemorrhage, Outcome, Survival",

author = "McCarron, {Mark O.} and Weir, {C. J.} and Muir, {K. W.} and Hoffmann, {K. L.} and C. Graffagnino and Nicoll, {J. A R} and Lees, {K. R.} and Alberts, {M. J.}",

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AU - McCarron, Mark O.

AU - Weir, C. J.

AU - Muir, K. W.

AU - Hoffmann, K. L.

AU - Graffagnino, C.

AU - Nicoll, J. A R

AU - Lees, K. R.

AU - Alberts, M. J.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

AB - Objective - To determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Material and methods - Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. Results - There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOE ε4 allele (P = 0.026) significantly reduced in-hospital survival. Conclusion - The APOE ε4 allele in this population may be associated with poor survival following ICH.

KW - Apolipoprotein E

KW - Intracerebral haemorrhage

KW - Outcome

KW - Survival

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Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage

Abstract

Keywords

ASJC Scopus subject areas

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