TY - JOUR
T1 - Effect of apnea duration on apnea induced variations in cerebral blood flow velocity and arterial blood pressure
AU - Alex, Raichel
AU - Manchikatla, Suvidha
AU - Machiraju, Karthik
AU - Altuwaijri, Essam
AU - Watenpaugh, Donald E.
AU - Zhang, Rong
AU - Behbehani, Khosrow
PY - 2014
Y1 - 2014
N2 - Obstructive Sleep Apnea (OSA), defined by shallow breaths or complete cessation of breathing for more than 10s, is a significant contributing factor for the developments of hypertension, myocardial infarction, stroke and neuropsychological impairments. In this study, we have investigated the relation between apnea duration and apnea induced variations in cerebral blood flow velocity (CBFV) concomitant with blood pressure changes in 9 sleep apnea subjects (8 male and 1 female; Age: 46.0±11.6 years; BMI: 34.5±7.8 kg/m(2); AHI: 81.6±41). As apnea duration increased from 10s to greater than 30s, the mean percentage rise in CBFV increased from 22% to 42% for amplitude and 22% to 33% for area respectively. For blood pressure, the values increased from 14% to 26% for amplitude and 14% to 23% for area respectively. The results suggest that the apnea duration has a measurable effect on the degree of rise in both cerebral blood flow velocity and arterial blood pressure during apnea episodes (p=0.0002).
AB - Obstructive Sleep Apnea (OSA), defined by shallow breaths or complete cessation of breathing for more than 10s, is a significant contributing factor for the developments of hypertension, myocardial infarction, stroke and neuropsychological impairments. In this study, we have investigated the relation between apnea duration and apnea induced variations in cerebral blood flow velocity (CBFV) concomitant with blood pressure changes in 9 sleep apnea subjects (8 male and 1 female; Age: 46.0±11.6 years; BMI: 34.5±7.8 kg/m(2); AHI: 81.6±41). As apnea duration increased from 10s to greater than 30s, the mean percentage rise in CBFV increased from 22% to 42% for amplitude and 22% to 33% for area respectively. For blood pressure, the values increased from 14% to 26% for amplitude and 14% to 23% for area respectively. The results suggest that the apnea duration has a measurable effect on the degree of rise in both cerebral blood flow velocity and arterial blood pressure during apnea episodes (p=0.0002).
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U2 - 10.1109/EMBC.2014.6943581
DO - 10.1109/EMBC.2014.6943581
M3 - Article
C2 - 25569949
SN - 1557-170X
VL - 2014
SP - 270
EP - 273
JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
ER -