Effect of acute exercise on postprandial endothelial function in postmenopausal women: A randomized cross-over study

Meena Shah, Sarah Bailey, Adam Gloeckner, Andreas Kreutzer, Beverley Adams-Huet, Dennis Cheek, Joel Mitchell

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


High-sugar intake may cause endothelial dysfunction. It is unknown if a bout of aerobic exercise improves endothelial dysfunction caused by a high-sugar meal in postmenopausal women. This study evaluated if prior aerobic exercise attenuates postprandial endothelial dysfunction in postmenopausal women. Twenty-two postmenopausal women (age [mean±SD]: 60.4±6.5 years; % body fat: 40.3%±7.5%) underwent an exercise (EX) or no exercise (NE) condition, in a random order, 13-16 hours prior to the high-sugar meal consumption. The EX condition included a 60 min bout of supervised aerobic exercise at 75% of age-predicted maximum heart rate. The high-sugar meal, consumed after a 12-hour fast, contained 33% of the subjects' daily energy needs, and 75.6% energy from carbohydrates. Flow-mediated dilation (FMD) and blood concentrations of glucose, insulin, endothelin-1 (ET-1), and nitric oxide (NO) were assessed at baseline and 60 min, 120 min, and 180 min postprandially. Repeated measures analysis test showed that there were no condition by time interaction or condition effects for FMD, glucose, insulin, or NO. There was a significant condition by time interaction but no condition effect for ET-1. Area under the curve was also not different by condition for insulin sensitivity or the above variables. In conclusion, prior aerobic exercise compared with NE did not affect FMD, blood glucose, insulin, ET-1 or NO concentrations, or insulin sensitivity following a high-sugar meal in postmenopausal women. Future studies should look at the effect of different EX intensities on meal-induced endothelial dysfunction in this population. Trial Registration: ClinicalTrials.gov Identifier: NCT02919488

Original languageEnglish (US)
Pages (from-to)964-970
Number of pages7
JournalJournal of Investigative Medicine
Issue number6
StatePublished - Aug 1 2019


  • acute exercise
  • endothelial dysfunction
  • endothelin-1
  • glucose
  • nitric oxide
  • postmenopausal women

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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