TY - JOUR
T1 - Early steps in the birth of four membrane-bound organelles—Peroxisomes, lipid droplets, lipoproteins, and autophagosomes
AU - Banerjee, Subhrajit
AU - Prinz, William A.
N1 - Funding Information:
This study was supported by the Intramural research program of the National Institute of Diabetes and Digestive and Kidney Diseases . Figures were Created with Biorender.com .
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/10
Y1 - 2023/10
N2 - Membrane-bound organelles allow cells to traffic cargo and separate and regulate metabolic pathways. While many organelles are generated by the growth and division of existing organelles, some can also be produced de novo, often in response to metabolic cues. This review will discuss recent advances in our understanding of the early steps in the de novo biogenesis of peroxisomes, lipid droplets, lipoproteins, and autophagosomes. These organelles play critical roles in cellular lipid metabolism and other processes, and their dysfunction causes or is linked to several human diseases. The de novo biogenesis of these organelles occurs in or near the endoplasmic reticulum membrane. This review summarizes recent progress and highlights open questions.
AB - Membrane-bound organelles allow cells to traffic cargo and separate and regulate metabolic pathways. While many organelles are generated by the growth and division of existing organelles, some can also be produced de novo, often in response to metabolic cues. This review will discuss recent advances in our understanding of the early steps in the de novo biogenesis of peroxisomes, lipid droplets, lipoproteins, and autophagosomes. These organelles play critical roles in cellular lipid metabolism and other processes, and their dysfunction causes or is linked to several human diseases. The de novo biogenesis of these organelles occurs in or near the endoplasmic reticulum membrane. This review summarizes recent progress and highlights open questions.
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U2 - 10.1016/j.ceb.2023.102210
DO - 10.1016/j.ceb.2023.102210
M3 - Review article
C2 - 37531895
AN - SCOPUS:85166530563
SN - 0955-0674
VL - 84
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
M1 - 102210
ER -