@article{ab7dea92b19244bb8c4fd12ea11c5863,
title = "Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma",
abstract = "Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling. We have generated mouse strains that lack p53 and harbor a conditional allele of the NF1 tumor suppressor that negatively regulates Ras signaling. The mice develop malignant astrocytomas with complete penetrance. The majority of tumors display characteristics of glioblastoma multiforme with concomitant alteration of signaling pathways previously described in the human counterparts of this neoplasm. We find that the sequence of tumor suppressor inactivation influences tumorigenicity and that earliest evidence of tumor formation localizes to regions of the brain that contain a multipotent stem cell population capable of in vivo differentiation into neurons and glia.",
author = "Yuan Zhu and Frantz Guignard and Dawen Zhao and Li Liu and Burns, {Dennis K.} and Mason, {Ralph P.} and Albee Messing and Parada, {Luis F.}",
note = "Funding Information: We thank A. DeShaw, P. Houston, and S. McKinnon for technical assistance; Dr. Q.R. Lu for an Olig2 antibody; members of the Parada lab for support; and Dr. S. Kernie for critically reading the manuscript. This work is supported by grants from the National Institute of Neurological Disorders and Stroke and the Department of Defense (L.F.P.). Y.Z. acknowledges support from the National Neurofibromatosis Foundation (Young Investigator Award), the Biological Sciences Scholars Program, and the Comprehensive Cancer Center (Munn Idea Award) of the University of Michigan Medical School, General Motors Cancer Research Scholar Program. D.Z. and R.P.M. thank Todd Soesbe for coil construction the National Cancer Institute for P20 Pre-ICMIC grant CA86354. ",
year = "2005",
month = aug,
doi = "10.1016/j.ccr.2005.07.004",
language = "English (US)",
volume = "8",
pages = "119--130",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}