Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress

J. B. Guild; A. B. Chromiak; E. A. Sprague; R. M. Nerem

Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress

J. B. Guild, A. B. Chromiak, E. A. Sprague, R. M. Nerem

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.

Original language	English (US)
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publisher	IEEE
Pages	4
Number of pages	1
ISBN (Print)	0780356756
State	Published - 1999
Externally published	Yes
Event	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA Duration: Oct 13 1999 → Oct 16 1999

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	1
ISSN (Print)	0589-1019

Other

Other	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
City	Atlanta, GA, USA
Period	10/13/99 → 10/16/99

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Guild, J. B., Chromiak, A. B., Sprague, E. A., & Nerem, R. M. (1999). Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 4). (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 1). IEEE.

Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress. / Guild, J. B.; Chromiak, A. B.; Sprague, E. A. et al.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. IEEE, 1999. p. 4 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Guild, JB, Chromiak, AB, Sprague, EA & Nerem, RM 1999, Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 1, IEEE, pp. 4, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

Guild, J. B. ; Chromiak, A. B. ; Sprague, E. A. et al. / Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. IEEE, 1999. pp. 4 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

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abstract = "Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.",

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AU - Sprague, E. A.

AU - Nerem, R. M.

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N2 - Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.

AB - Our aim is to study the hemodynamic alteration of monocyte recruitment and adhesion in model blood vessel systems, focusing on the hemodynamic effects of the recruitment factor monocyte chemotactic protein one, MCP-1, gene expression in HAEC. Preconditioning with low shear stress, LS, elevates MCP-1 gene activity and eliminates any transient peak in activity upon switching to high shear stress, HS, without affecting HS-induced gene down-regulation. These data suggest an interaction between the pathways mediating the long term response to LS and the transient cellular response to HS onset.

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ER -

Dynamic MCP-1 mRNA response of human aortic endothelial cells (HAEC) to step changes in laminar shear stress

Abstract

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