Durability of the Prostatic Urethral Lift: 2-Year Results of the L.I.F.T. Study

Claus Roehrborn, Steven N. Gange, Neal D. Shore, Jonathan L. Giddens, Damien M. Bolton, Barrett E. Cowan, Anthony L. Cantwell, Kevin T. McVary, Alexis E. Te, Shahram S. Gholami, Prem Rashid, William G. Moseley, Peter T. Chin, William T. Dowling, Sheldon J. Freedman, Peter F. Incze, K. Scott Coffield, Fernando D. Borges, Daniel B. Rukstalis

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Introduction: For a therapy to become an important part of a provider armamentarium it must be safer or better than existing therapies and be durable. The prostatic urethral lift offers rapid improvement in lower urinary tract symptoms associated with benign prostatic hyperplasia with minimal side effects. We report 2-year results of a multicenter, randomized, blinded trial of the prostatic urethral lift. Methods: A total of 206 men 50 years old or older with an AUA-SI of 13 or greater, a peak flow rate of 12 ml per second or less and a 30 to 80 cc prostate were randomized 2:1 between the prostatic urethral lift and sham treatment. The prostatic urethral lift is performed by placing permanent transprostatic implants to lift apart the prostate lobes and reduce urethral obstruction. Sham treatment entailed rigid cystoscopy, a blinding screen and sounds that mimicked those of the prostatic urethral lift procedure. Patients were assessed for lower urinary tract symptoms, peak flow rate, quality of life and sexual function. Results: The prostatic urethral lift reduced the AUA-SI 88% more than sham treatment (-11.1 vs -5.9, p=0.003). Patients with the prostatic urethral lift experienced an AUA-SI reduction from 22.1 at baseline to18.0 (-17%), 11.1 (-50%), 11.4 (-48%) and 12.5 (-42%) at 2 weeks, 3 months, and 1 and 2 years, respectively (p<0.0001). The peak flow rate was increased 4.2 ml per second at 3 months and 2 years (p<0.0001). By 2years only 7.5% of patients required additional intervention for lower urinary tract symptoms. Adverse events were typically mild and transient. Encrustation did not develop on implants properly placed inthe prostate. There was no occurrence of de novo sustained ejaculatory or erectile dysfunction. Conclusions: The prostatic urethral lift preserves sexual function and provides rapid improvement in symptoms, flow and quality of life that are sustained to 2 years.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalUrology Practice
Issue number1
StatePublished - 2015


  • Benign prostatic hyperplasia
  • Minimally invasive surgical procedures
  • Prostate
  • Prostheses and implants
  • Urethra

ASJC Scopus subject areas

  • Urology


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