Drivers of EMT and Immune Evasion

Rolf A. Brekken; Katarzyna Wnuk-Lipinska

doi:10.1007/978-3-030-98950-7_11

Drivers of EMT and Immune Evasion

Rolf A. Brekken, Katarzyna Wnuk-Lipinska

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The heterogeneity of tumor cells and the complexity of the surrounding microenvironment make the process of predicting patient outcomes and selection of the most suitable treatment regimen very difficult. Many biomarkers have been evaluated for prognostic value with success more consistently seen with targeted therapy. The advent of immune therapy as a frontline treatment for some cancers has moved immune phenotyping into the forefront of biomarker and predictive marker research. Here, we review some of the regulatory mechanisms of the host immune response and epithelial plasticity and highlight their potential as biomarkers of the hallmark of immune evasion.

Original language	English (US)
Title of host publication	Biomarkers of the Tumor Microenvironment, Second Edition
Publisher	Springer International Publishing
Pages	183-194
Number of pages	12
ISBN (Electronic)	9783030989507
ISBN (Print)	9783030989491
DOIs	https://doi.org/10.1007/978-3-030-98950-7_11
State	Published - Jan 1 2022

Keywords

EMT
Immunosuppression
Inflammation
Phosphatidylserine
TAM receptors

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-030-98950-7_11

Cite this

@inbook{9a43c085cfdf41009ab5a6330b8309eb,

title = "Drivers of EMT and Immune Evasion",

abstract = "The heterogeneity of tumor cells and the complexity of the surrounding microenvironment make the process of predicting patient outcomes and selection of the most suitable treatment regimen very difficult. Many biomarkers have been evaluated for prognostic value with success more consistently seen with targeted therapy. The advent of immune therapy as a frontline treatment for some cancers has moved immune phenotyping into the forefront of biomarker and predictive marker research. Here, we review some of the regulatory mechanisms of the host immune response and epithelial plasticity and highlight their potential as biomarkers of the hallmark of immune evasion.",

keywords = "EMT, Immunosuppression, Inflammation, Phosphatidylserine, TAM receptors",

author = "Brekken, {Rolf A.} and Katarzyna Wnuk-Lipinska",

note = "Publisher Copyright: {\textcopyright} The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017, 2022.",

year = "2022",

month = jan,

day = "1",

doi = "10.1007/978-3-030-98950-7_11",

language = "English (US)",

isbn = "9783030989491",

pages = "183--194",

booktitle = "Biomarkers of the Tumor Microenvironment, Second Edition",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Drivers of EMT and Immune Evasion

AU - Brekken, Rolf A.

AU - Wnuk-Lipinska, Katarzyna

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017, 2022.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - The heterogeneity of tumor cells and the complexity of the surrounding microenvironment make the process of predicting patient outcomes and selection of the most suitable treatment regimen very difficult. Many biomarkers have been evaluated for prognostic value with success more consistently seen with targeted therapy. The advent of immune therapy as a frontline treatment for some cancers has moved immune phenotyping into the forefront of biomarker and predictive marker research. Here, we review some of the regulatory mechanisms of the host immune response and epithelial plasticity and highlight their potential as biomarkers of the hallmark of immune evasion.

AB - The heterogeneity of tumor cells and the complexity of the surrounding microenvironment make the process of predicting patient outcomes and selection of the most suitable treatment regimen very difficult. Many biomarkers have been evaluated for prognostic value with success more consistently seen with targeted therapy. The advent of immune therapy as a frontline treatment for some cancers has moved immune phenotyping into the forefront of biomarker and predictive marker research. Here, we review some of the regulatory mechanisms of the host immune response and epithelial plasticity and highlight their potential as biomarkers of the hallmark of immune evasion.

KW - EMT

KW - Immunosuppression

KW - Inflammation

KW - Phosphatidylserine

KW - TAM receptors

UR - http://www.scopus.com/inward/record.url?scp=85163427421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85163427421&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-98950-7_11

DO - 10.1007/978-3-030-98950-7_11

M3 - Chapter

AN - SCOPUS:85163427421

SN - 9783030989491

SP - 183

EP - 194

BT - Biomarkers of the Tumor Microenvironment, Second Edition

PB - Springer International Publishing

ER -

Drivers of EMT and Immune Evasion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this