Drivers of EMT and immune evasion

Rolf A. Brekken, Katarzyna Wnuk-Lipinska

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The heterogeneity of tumor cells and the complexity of the surrounding microenvironment make the process of predicting patient outcome and selection of the most suitable treatment regimen very difficult. Over the past decades, many biomarkers have been evaluated for prognostic value. The advent of immune therapy as a frontline treatment for some cancers has moved immune phenotyping into the forefront of biomarker and predictive marker research. Here, we review some of the regulatory mechanisms of the host immune response and epithelial plasticity and highlight their potential as biomarkers of the hallmark of immune evasion.

Original languageEnglish (US)
Title of host publicationBiomarkers of the Tumor Microenvironment
Subtitle of host publicationBasic Studies and Practical Applications
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783319391472
ISBN (Print)9783319391458
StatePublished - Aug 2 2017


  • EMT
  • Immunosuppression
  • Inflammation
  • Phosphatidylserine
  • TAM receptors

ASJC Scopus subject areas

  • General Medicine


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