Abstract
We identified a Drosophila gene encoding a homolog of the regulator of G-protein signaling (RGS) protein family. This gene (dRGS7) is expressed in neurons of the embryo and adult fly and is predicted to encode a 428-amino acid protein with >55% overall amino acid sequence identity with the vertebrate protein RGS7 and the C. elegans EGL-10. The dRGS7 protein is 50% conserved in the C-terminal RGS domain with RGS7 and EGL-10 but, remarkably, displays much greater conservation with the N-terminal regions of these proteins. This finding implies a conserved function for these homologs from divergent species involving domains outside the RGS domain. The dRGS7 protein also has a domain of similarity with Dishevelled and pleckstrin, raising the possibility that these proteins interact with common signaling components.
Original language | English (US) |
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Pages (from-to) | 983-989 |
Number of pages | 7 |
Journal | DNA and Cell Biology |
Volume | 17 |
Issue number | 11 |
DOIs | |
State | Published - 1998 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cell Biology